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. Author manuscript; available in PMC: 2012 Dec 7.

Published in final edited form as: ChemMedChem. 2011 Jun 28;6(8):1335–1318. doi: 10.1002/cmdc.201100177

Inhibition of single round cell infection by KR13 (circles) and AuNP-KR13 (squares). (A) Inhibition of infection of HOS.T4.R5 cells by recombinant viruses pseudotyped with the envelope for HIV-1_BaL (solid) or with the envelope for VSV-G (open). The data were normalized to 100% infection activity at 0 µM concentration of KR13. The calculated IC₅₀ of KR13 alone was 23 ± 6 nM, n=4; that of the AuNP-KR13 conjugate was 1 ± 0.1 nM n=3. Efficacy parameters were calculated using sigmoidal logistic fit in Origin Pro 8 software. B) Cell toxicity assay using WST-1 reagent; no statistically significant differences measured, P<<<0.05, n =3 using a t test.

Inhibition of single round cell infection by KR13 (circles) and AuNP-KR13 (squares). (A) Inhibition of infection of HOS.T4.R5 cells by recombinant viruses pseudotyped with the envelope for HIV-1_BaL (solid) or with the envelope for VSV-G (open). The data were normalized to 100% infection activity at 0 µM concentration of KR13. The calculated IC₅₀ of KR13 alone was 23 ± 6 nM, n=4; that of the AuNP-KR13 conjugate was 1 ± 0.1 nM n=3. Efficacy parameters were calculated using sigmoidal logistic fit in Origin Pro 8 software. B) Cell toxicity assay using WST-1 reagent; no statistically significant differences measured, P<<<0.05, n =3 using a t test.