Table 2.

Differentially Expressed Proteins in 4–9 mos. Treatment groups

Protein Identified	WT H2O vs. WT NACa		WT H2O vs. APP/PS-1 H2Ob		APP/PS-1 H2O vs. APP/PS-1 NACc
	Ratio	p-value	Ratio	p-value	Ratio	p-value
Fructose-bisphosphate aldolase A	142.59	<0.04
Superoxide dismutase 2	6.75	<0.04
Synaptosomal-associated protein 25-A			20.52	<0.0003
V-type proton ATPase subunit B, brain isoform			16.20	<0.03
Cytochrome c oxidase subunit 5A, mitochondrial			4.19	<0.02
ATP synthase subunit alpha, mitochondrial*			0.35	<0.02
ATP synthase subunit d, mitochondrial			0.35	<0.04
Heat shock protein HSP 90-alpha			0.28	<0.01
Fructose-bisphosphate aldolase C			0.28	<0.04
Aconitate hydratase, mitochondrial			0.28	<0.04
Glyceraldehyde-3-phosphate dehydrogenase			0.28	<0.02
Alpha-enolase			0.02	<0.02
ATP synthase subunit alpha, mitochondrial*			0.01	<0.02
Calbindin			0.005	<0.0003
Glutamate dehydrogenase 1, mitochondrial					1.88	<0.03

^*See Figure 1 for the location of these spots

^aRatio represents the average protein spot density WT NAC/ average protein spot density WT H₂O. N=8 for WT H₂O and N=9 for WT NAC.

^bRatio represents the average protein spot density APP/PS-1 H₂O/average protein spot density WT H₂O. N=6 for for WT H₂O and N=9 for APP/PS-1 H₂O.

^cRatio represents the average protein spot density APP/PS-1 NAC/average protein spot density APP/PS-1 H₂O. N=9 for each group.

^dListings in bold are statistically significantly different from the respective control.