Table 3.

Conjugate Addition of Acetone Cyanohydrin to 7.^a

Entry	7	R	PTC	Time (h)	Yieldb	eec
1d	7a	Et	CPD-2	24	>95e	86
2d	7a	Et	CPN-3	24	>95e	78
3	7a	Et	CPD-2	48	83	95 (S)
4	7a	Et	CPN-3	24	94	90 (R)
5	7b	Me	CPD-2	48	79	97 (S)
6	7b	Me	CPN-3	24	77	92 (R)
7	7c	n-C5H11	CPD-2	96	87	96 (S)
8	7c	n-C5H11	CPN-3	24	84	92 (R)
9	7d	iPr	CPD-2	48	83	95 (S)
10	7d	iPr	CPN-3	24	71	91 (R)
11	7e	CH2iPr	CPD-2	96	78	98 (S)
12	7e	CH2iPr	CPN-3	24	80	94 (R)
13	7f	CH2CH2Ph	CPD-2	96	75	95 (S)
14	7f	CH2CH2Ph	CPN-3	24	70	93 (R)

^aUnless noted reactions were performed with 0.1 mmol of 7 and 0.2 mmol acetone cyanohydrin, 0.12 mmol Rb₂CO₃ in 1 mL of Toluene/CHCl₃ (7:3 v/v) with 10 mol% CPD-2(or 10 mol% CPN-3a).

^bIsolated yield.

^cDetermined by chiral HPLC. The Absolute configuration is reported in parenthesis, see supporting information for details.

^d0.12 mmol Cs₂CO₃ used instead of Rb₂CO₃