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(Top) The chemical structures of ACT058362 in green and SB-706375 in orange with its hybrid compound in cyan. (Bottom) the superimposition of the lowest E conformers of these compounds through atom-by-atom fitting among three atoms marked with asterisks. The root mean square deviation (RMSD) are 0.63 (for N+, Nar, Cal of ACT-058362 to N+, Nar, Cal of ACT-SB hybrid) and 1.12 Å (for N+, S, Car of SB-706375 to N+, S, Car of ACT-SB hybrid).
