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Optimization of the α-Hydroxyl Acetophenone Aldol Reaction
| |||||
|---|---|---|---|---|---|
| Entry | R | Solvent | syn: anti | de of syn (%) | Isolated yield (%), (cmpd) |
| 1 | TBS | THF | 4.8: 1 | 91 | 52 (47) |
| 2 | PMB | THF | 5: 1 | 92 | 69 (48) |
| 3 | PMB | Toluene | 9: 1 | 94 | 83 (48) |
| 4 | PMB | MeCN | 7.5: 1 | 90 | 70 (48) |
| 5 | PMB | DCM | 6: 1 | 88 | 51 (48) |
