Table 2.
Initial Optimization of the Acyl Pyrrole Aldol Reaction
| |||||
|---|---|---|---|---|---|
| Entry | P | R | Yield (%) | syn: anti | de (syn) |
| 1 | TBS | H | 80 | 1.5: 1 | 86 |
| 2 | TBDPS | H | 85 | 1.1: 1 | 68 |
| 3 | PMB | H | 70 | 1.1: 1 | 41 |
| 4 | MTM | H | 25 | 1.9: 1 | 60 |
| 5 | TBS | Et | 80 | 4: 1 | ND |
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