Table 3.
Ru-catalyzed ene-yne/Michael addition optimization.
| Entry | Concentration (M) | Catalyst loading (x mol%) | 48a:10 | Yield 49a (50a) |
|---|---|---|---|---|
| 1 | 0.1 | 10 | 1 | 31% |
| 2 | 0.1 | 10 | 1.8 | 43% (6%) |
| 3 | 0.4 | 10 | 1.2 | 41% (6%) |
| 4 | 0.1 | 30 | 1 | 36% |
| 5 | 0.4 | 10 | 3 | 68 (15%) |
 | ||||
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