Table 4.
Tandem alkyne-enone coupling/Michael addition reaction.
 | |||
|---|---|---|---|
| Entry | R1 | R2 | Yield 49 (recovered 48 equiv.) |
| 1 | t-Bu | Et | 80% |
| 2 | n-Hex | Et | 62% |
| 3 |  |
CH2OPMB (10) | 69% (1.8) |
| 4 |  |
CH2OPMB (10) | 58% |
| 5 |  |
CH2OPMB (10) | 77% (1.9) |
| 6 |  |
CH2OPMB (10) | 39% (1.9) |
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