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. Author manuscript; available in PMC: 2013 Sep 24.
Published in final edited form as: Chembiochem. 2012 Sep 7;13(14):2113–2121. doi: 10.1002/cbic.201200381

Figure 5.

Figure 5

C107 effects on dynamic cellular histone acetylation. Quiescent C3H 10T1/2 mouse fibroblasts were treated with C646 or C107 for 1 h, followed by harvesting or addition of TSA (trichostatin A, 33 nM) for a further 30 min before harvesting. Histones were extracted and analyzed by Acid-Urea gel. These gels separate histones based on their charge, with individual acetylation events slowing the migration to produce a ‘ladder’ of bands. The numbers on either side of the blot indicate the number of acetyl moieties present on each molecule migrating at these positions. Note that methylation does not affect migration.