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(A) Capillary LC-MS chromatograms of bovine histone standard, and histones extracted from three human breast cancer cell lines, 0.5% formic acid, 5 μL/min, C8 column, 0.3 mm × 150 mm, 5 μm, 300 Å. Data were collected on an LCQ DecaXP. (B) Reconstructed mass spectra of H4 from Figure 9A using the Xtract deconvolution software (Thermo FisherScientific, San Jose, CA). Data were collected on an LTQ Orbitrap XL.
