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AICAR Tfase inhibition by CRYFNV alanine-scanning analogues.
| Compound | Sequence | Ki |
|---|---|---|
| 1 | cyclo-CRYFNV | 17 ± 3 μM |
| 2 | cyclo-ARYFNV | 651 ± 25 μM |
| 3 | cyclo-CAYFNV | > 2.5 mM |
| 4 | cyclo-CRAFNV | > 2.5 mM |
| 5 | cyclo-CRYANV | 38 ± 5 μM |
| 6 | cyclo-CRYFAV | 368 ± 29 μM |
| 7 | cyclo-CRYFNA | 252 ± 22 μM |
