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. Author manuscript; available in PMC: 2013 Oct 15.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Sep 24;51(42):10588–10591. doi: 10.1002/anie.201204633

Table 1.

Optimization of reaction conditions.

graphic file with name nihms416947u3.jpg
Entry Ligand Base Solvent Yield
1 Xphos Cs2CO3 Toluene 55%
2 tBuXphos Cs2CO3 Toluene 49%
3 Xantphos Cs2CO3 Toluene 61%
4 DPPF Cs2CO3 Toluene 68%
5 PPh3 Cs2CO3 Toluene 0%
6 PtBu3 Cs2CO3 Toluene 0%
7 DPPF KOtBu Toluene 51%
8 DPPF K3PO4 Toluene 0%
9 DPPF Cs2CO3 Dioxane trace
10 DPPF Cs2CO3 DMF 14%
11a DPPF Cs2CO3 Toluene 0%
a

Pd2dba3 was replaced with Pd(OAc)2.