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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Integr Biol (Camb). 2012 Dec;4(12):10.1039/c2ib20197f. doi: 10.1039/c2ib20197f

Figure 6. Multivariate analysis of kinase activation successfully predicted patient-specific cathepsin proteolytic activity of monocyte derived macrophages and osteoclasts.

Figure 6

Predictability of cathepsins K, L, S, and V activity in cell extracts using a PLSR model trained with kinase measurements of differentiating macrophages (A) (R2Y = 0.837, Q2 = 0.618, 1 significant PC) or of differentiating osteoclasts (B) (R2Y = 0.564, Q2 = −0.0823, 1 significant PC).