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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Aug 17;64(13):1363–1384. doi: 10.1016/j.addr.2012.08.005

Figure 2.

Figure 2

Mechanisms for the transport and accumulation of albumin-bound paclitaxel in tumors. Binding of albumin-bound paclitaxel complexes to the gp60 receptor and subsequent caveolin-1 mediated transcytosis results in transport across the endothelial barrier of the tumor vasculature. SPARC, an albumin-binding protein present in the tumor interstitium, enhances accumulation of the complexes in tumor tissue. Figure taken from reference [59].