Table 1.
Projections in the absence of competing cause of death | ||||||
---|---|---|---|---|---|---|
Overdiagnosis rate among screen detections |
Hazard ratio for disease-specific mortality associated with screening |
Incidence rate of non-overdiagnosed cancers in the screened arm |
Disease-specific survival in screened arm in the absence of screening |
Disease-specific survival in screened arm in the presence of screening |
Recipricol of deaths prevented by screening (NNS) |
Overdiagnoses relative to deaths prevented by screening (additional NNT) |
O | H | N = S(1−O) + C | P = NR + (1 − N) | PH | 1/ (PH − P) | O×S / (PH − P) |
0.58 | 0.80 | 0.048 | 0.972 | 0.977 | 178.35 | 6.01 |
0.58 | 0.56 | 0.048 | 0.972 | 0.984 | 80.79 | 2.72 |
0.42 | 0.80 | 0.054 | 0.968 | 0.975 | 159.48 | 4.45 |
0.42 | 0.56 | 0.054 | 0.968 | 0.982 | 72.21 | 2.01 |
0.23 | 0.80 | 0.069 | 0.960 | 0.968 | 126.27 | 1.69 |
0.23 | 0.56 | 0.069 | 0.960 | 0.977 | 57.11 | 0.76 |
Projections in the presence of competing causes of death | |||||
Overdiagnosis rate among screen detections |
Hazard ratio for disease-specific mortality associated with screening |
Cumulative incidence of disease-specific mortality in screened arm |
Cumulative incidence of disease-specific mortality in control arm |
Recipricol of deaths prevented by screening (NNS) |
Overdiagnoses relative to deaths prevented by screening (additional NNT) |
O | H | Ms | Mc | 1/(Mc − Ms) | O×S/(Mc − Ms) |
0.58 | 0.80 | 0.015 | 0.019 | 262.49 | 8.85 |
0.58 | 0.56 | 0.011 | 0.019 | 118.76 | 4.00 |
0.42 | 0.80 | 0.018 | 0.023 | 219.83 | 5.36 |
0.42 | 0.56 | 0.013 | 0.023 | 99.96 | 2.44 |
0.23 | 0.80 | 0.022 | 0.027 | 185.95 | 2.48 |
0.23 | 0.56 | 0.015 | 0.027 | 83.92 | 1.12 |