Figure 2.  .

Effect of streptozotocin diabetes and treatment with Ilepatril on thermal nociception and intraepidermal nerve fiber density. Top: Representative image of intraepidermal nerve fibers (white arrows) in skin from the hindpaw from a control rat. Bottom: Thermal nociception and intraepidermal nerve fiber density was examined as described in the Methods section. Data are presented as the mean ± SEM for thermal nociception in seconds and intraepidermal nerve fiber profiles per millimeter. The number of rats in each group was the same as shown in Table 1. *P < 0.05 compared to control rats; +P < 0.05 compared to diabetic rats.