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. Author manuscript; available in PMC: 2012 Dec 7.
Published in final edited form as: Cancer Res. 2011 Jul 14;71(14):4834–4845. doi: 10.1158/0008-5472.CAN-11-0027

Figure 7.

Figure 7

HNSC graft–derived cells express behaviorally induced Arc in the irradiated hippocampus. Irradiated animals engrafted with hNSCs and subjected to a hippocampal-dependent novelty exploration task at 1 month postgrafting were rapidly processed for the isolation and analysis of brain tissues. Engrafted hNSCs (BrdUrd + cells, green; A, C, G, and K) + differentiated into NeuN-positive mature neurons (blue; A, D, H, and L) and expressed Arc (red; A, B, F, and J) as visualized by the triple labeling of neuron- and Arc-specific markers (A, E, I, and M). Arrows indicate triple-labeled cells. Scale bars: A, 50 μm; B–M, 10 μm.