Figure 2. Comparison of the anti-B. pseudomallei activity of spermine NONOate and DETA NONOate.

The bacteria were exposed to 250 μg/ml DETA, 250 μg/ml DETA NONOate, 1 mg/ml spermine, or 1 mg/ml spermine NONOate as described for the experiments in table 1. Control represents the polyamine parent compound, whereas NONOate is the NO releasing derivative. The fraction of surviving bacteria was recorded 2.5 h after challenge. The data are the mean ± SD from 8 individual observations from 2 separate experiments.