Table 4.
Cost effectiveness analysis of base case, health care provider perspective, and additional sensitivity analyses.
| Cost drivers | Base case: societal |
Alternative case: health care provider |
Sensitivity analyses | ||||||
| Ia –40% | I +40% | Pb –40% | P +40% | I and P –40% |
I and P +40% |
||||
| Incremental costs (median) | 845 | 271 | 739 | 954 | 681 | 1012 | 573 | 1120 | |
| Treatment response | |||||||||
| Incremental effects (median) | 0.24 | 0.24 | 0.24 | 0.24 | 0.24 | 0.24 | 0.24 | 0.24 | |
| ICERc (median) | 3683 | 1157 | 3187 | 4172 | 2977 | 4387 | 2494 | 4868 | |
| ICER (95%low) | –5703 | 665 | –6441 | –5050 | –3227 | –8313 | –3821 | –7576 | |
| ICER (95%high) | 20,366 | 3722 | 19,410 | 21,409 | 14,724 | 25,979 | 13,738 | 26,957 | |
| WTPd €4000 | 53% | 95% | 57% | 50% | 62% | 48% | 66% | 46% | |
| WTP €8000 | 76% | 98% | 78% | 74% | 85% | 69% | 87% | 67% | |
| WTP €12,000 | 87% | 99% | 89% | 86% | 92% | 82% | 93% | 80% | |
| Upper right quadrant | 79% | 99% | 76% | 82% | 83% | 76% | 79% | 79% | |
| Upper left (inferior) quadrant | 1% | 1% | 1% | 1% | 1% | 1% | 1% | 1% | |
| Lower left quadrant | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | |
| Lower right (dominant) quadrant | 20% | 0% | 23% | 17% | 16% | 22% | 20% | 20% | |
| QALYse | |||||||||
| Incremental QALYs (median) | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | 0.06 | |
| ICER QALY (median) | 14,710 | 4693 | 12,932 | 16,584 | 11,876 | 17,683 | 9946 | 19,436 | |
| ICER QALY (95%low) | –18,337 | 2783 | –20,177 | –16,241 | –10,291 | –26,220 | –12,282 | –24,352 | |
| ICER QALY (95%high) | 71,664 | 10,848 | 67,913 | 75,671 | 52,202 | 91,101 | 48,403 | 94,958 | |
| WTP €10,000 | 40% | 95% | 45% | 36% | 44% | 38% | 50% | 35% | |
| WTP €20,000 | 60% | 99% | 64% | 57% | 70% | 54% | 74% | 51% | |
| WTP €40,000 | 85% | 100% | 87% | 83% | 93% | 77% | 94% | 74% | |
| Upper right quadrant | 80% | 100% | 76% | 83% | 84% | 77% | 80% | 80% | |
| Upper left (inferior) quadrant | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | |
| Lower left quadrant | 0% | 0% | 0% | 0% | 0% | 0% | 0% | 0% | |
| Lower right (dominant) quadrant | 20% | 0% | 23% | 17% | 16% | 23% | 20% | 20% | |
a Intervention costs.
b Productivity costs.
c Incremental cost effectiveness ratio.
d Willingness to pay.
e Quality-adjusted life-year.