Figure 3. Network representation of genes up- and down-regulated during and after the heat shock.

Modularity of networks of down-regulated genes was significantly lower than that of up-regulated networks. The induction of genes belonging to a metabolic pathway or cellular function was more synchronized than their down-regulation because of the hysteretic transcriptional response or persistence of the induction of the majority of genes induced by the heat shock once the temperature is set back to 25°C. Different colours represent different modules in each network.