Table 3.
Summary of studies that have examined hepatotoxicity rates in patients with paracetamol overdose
| Author | Year | Location | n | Hepatotoxicity % | Survival % | Paracetamol Dose |
|---|---|---|---|---|---|---|
| Proudfoot
[22] |
1970 |
Edinburgh, U.K. |
41 |
39% |
97.6% |
39% > 15 g |
| Schiodt
[14] |
1997 |
Texas, U.S. |
71 |
32% |
93% |
Median = 17.6 g 93% > 4 g |
| Hawton
[17] |
1996 |
Oxford, U.K. |
80 |
31% |
NA |
69% > 12.5 g |
| Gyamlani
[15] |
2001 |
New York, USA |
93 |
16% |
98% |
NA |
| James
[16] |
2008 |
USA |
157 |
15% (1.3% ALF) |
100% |
Mean 18 g |
| Ayonrinde
[5] |
2005 |
Australia |
188 |
14% |
100% |
Median = 12 g |
| Mohd-Zain
[9] |
2006 |
Penang, Malaysia |
165 |
7.3% |
100% |
38% > 10 g |
| Current study |
2011 |
Kuala Lumpur , Malaysia |
1024 |
7.5% |
100% |
Median 10 g (54.3% > 10 g) |
| Chan
[10] |
1993 |
Hong Kong |
104 |
6% |
100% |
Median 5 g 6.7% > 10 g |
| Mills
[19] |
2008 |
Jamaica |
49 |
2% |
100% |
Range 2–30 g |
| Schmidt [18] | 2002 | Copenhagen, Denmark | 737 | No data on hepatotoxicity (0.9% ALF) | 99.9% | Median 25 g |