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. 2012 Oct 19;12:481. doi: 10.1186/1471-2407-12-481

Figure 3.

Figure 3

Schematic diagram of PTEN promoter. (A) Core promoter of PTEN localized between −1345 to −745 is shown. The beginning of exon 1 is designated as (0) and the start codon “ATG” within the first exon is indicated. A 1030 bp long leader sequence (LS) is found between the beginning of the first exon and the ATG site. The gray area between −958 and −821 is the minimal promoter of PTEN. Binding sites for the main transcription factors within the core promoter region are shown. (B) The EP-PTEN, CP-PTEN and Δ mut. CP-PTEN promoter constructs used in this study are shown. All promoter regions were cloned into the luciferase expressing plasmid pGL3 (Luc).