Table 5.
Multivariate logistic regression analysis of predictive factors of treatments administered
| Variables | OR | 95% CI | p value |
|---|---|---|---|
|
Predictive factors for surgery alone * (N=537) | |||
| Age |
|
|
0.06 |
| 75-79 |
1 |
|
|
| 80-84 |
1.28 |
0.57-2.88 |
|
| ≥85 |
2.52 |
1.15-5.54 |
|
| N stage |
|
|
0.05 |
| N0 |
1 |
|
|
| N+ |
0.36 |
0.13-1.01 |
|
| Hormone receptors |
|
|
0.008 |
| Negative |
1 |
|
|
| Positive |
0.29 |
0.12-0.72 |
|
| Period |
|
|
0.008 |
| 1998-2003 |
1 |
|
|
| 2004-2008 |
0.40 |
0.20-0.78 |
|
| Histoprognostic SBR grade |
|
|
0.25 |
| 1+2 |
1 |
|
|
| 3 |
1.59 |
0.72-3.49 |
|
| Place of residence |
|
|
0.16 |
| Rural |
1 |
|
|
| Urban |
1.84 |
0.78-4.33 |
|
|
Predictive factors for hormone therapy alone (N=452) | |||
| Age |
|
|
<0.001 |
| 75-79 |
1 |
|
|
| 80-84 |
2.07 |
0.80-5.35 |
|
| ≥85 |
16.22 |
6.74-39.03 |
|
| T stage |
|
|
|
| T0+T1 |
1 |
|
0.89 |
| T2 |
1.21 |
0.53-2.74 |
|
| T3+T4 |
1.22 |
0.42-3.52 |
|
| N stage |
|
|
0.52 |
| N0 |
1 |
|
|
| N+ |
1.32 |
0.57-3.07 |
|
| M stage |
|
|
0.02 |
| M0 |
1 |
|
|
| M1 |
3.67 |
1.25-10.74 |
|
| Comorbidities |
|
|
<0.001 |
| No |
1 |
|
|
| Yes |
7.59 |
2.45-23.56 |
|
| Histoprognostic SBR grade |
|
|
0.22 |
| 1+2 |
1 |
|
|
| 3 |
0.55 |
0.21-1.43 |
|
| Period |
|
|
0.23 |
| 1998-2003 |
1 |
|
|
| 2004-2008 |
1.56 |
0.75-3.24 |
|
| Hormone receptors |
|
|
0.07 |
| Negative |
1 |
|
|
| Positive |
4.73 |
0.90-24.94 |
|
| Diagnosis circumstances |
|
|
0.55 |
| Clinic |
1 |
|
|
| Individual screening |
0.72 |
0.24-2.13 |
|
| Place of residence |
|
|
1 |
| Rural |
1 |
|
|
| Urban |
1 |
0.47-2.12 |
|
|
Predictive factors for BCS plus adjuvant therapy † (N=381) | |||
| Age |
|
|
<0.001 |
| 75-79 |
1 |
|
|
| 80-84 |
0.53 |
0.30-0.95 |
|
| ≥85 |
0.21 |
0.09-0.50 |
|
| T stage |
|
|
<0.001 |
| T0 +T1 |
1 |
|
|
| T2 |
0.17 |
0.09-0.31 |
|
| T3+T4 |
0.13 |
0.05-0.30 |
|
| N stage |
|
|
0.23 |
| N0 |
1 |
|
|
| N+ |
0.64 |
0.31-1.33 |
|
| Comorbidities |
|
|
0.11 |
| No |
1 |
|
|
| Yes |
0.62 |
0.34-1.12 |
|
| Diagnosis circumstances |
|
|
0.10 |
| Clinic |
1 |
|
|
| Individual screening |
1.71 |
0.90-3.24 |
|
| Histoprognostic SBR grade |
|
|
0.30 |
| 1+2 |
1 |
|
|
| 3 |
0.7 |
0.36-1.37 |
|
| Matrimonial status |
|
|
0.40 |
| Single‡ |
1 |
|
|
| Not single |
1.26 |
0.73-2.17 |
|
| Hormone receptors |
|
|
0.78 |
| Negative |
1 |
|
|
| Positive |
1.14 |
0.46-2.83 |
|
|
Predictive factors for mastectomy plus adjuvant therapy (N=381) | |||
| T stage |
|
|
<0.001 |
| T0+T1 |
1 |
|
|
| T2 |
5.57 |
3.09-10.03 |
|
| T3+T4 |
3.60 |
1.78-7.29 |
|
| N stage |
|
|
0.61 |
| N0 |
1 |
|
|
| N+ |
0.86 |
0.49-1.53 |
|
| M stage |
|
|
0.07 |
| M0 |
1 |
|
|
| M1 |
0.47 |
0.21-1.08 |
|
| Histoprognostic SBR grade |
|
|
0.005 |
| 1+2 |
1 |
|
|
| 3 |
2.18 |
1.26-3.76 |
|
| Matrimonial status |
|
|
0.19 |
| Single‡ |
1 |
|
|
| Not single |
0.72 |
0.44-1.18 |
|
| Place of residence |
|
|
0.22 |
| Rural |
1 |
|
|
| Urban |
0.73 |
0.44-1.20 |
|
| Age x diagnosis circumstances § |
|
|
<0.001 |
| 75-79 x clinical diagnosis |
1 |
|
|
| 80-84 x clinical diagnosis |
1.63 |
0.91-2.93 |
|
| ≥85 x clinical diagnosis |
0.26 |
0.13-0.52 |
|
| 75-79 x individual screening |
0.45 |
0.17-1.18 |
|
| 80-84 x individual screening |
0.33 |
0.09-1.18 |
|
| ≥85 x individual screening | 1.25 | 0.24-6.38 | |
Abbreviations: OR = Odds Ratios; CI = confidence interval, N = number of patients.
*Predictive factors for surgery alone without the variable M stage because no patient with stage M1 had surgery alone.
†Predictive factors for BCS plus adjuvant therapy without the variable M stage because only 4 patients with stage M1 received BCS plus adjuvant therapy.
‡patient single, divorced or widowed.
§Interaction age and diagnosis circumstances.
NB: Multivariate logistic regression analyses were adjusted for age, TNM stage, period, diagnosis circumstances, comorbidities, histoprognostic SBR grade, tumour type, hormone receptors, matrimonial status, and place of residence.