Table 1. Otomicroscopic analysis of the healing of TM perforations in WT, tPA−/− and uPA−/− mice.
Number of days after perforation | |||||
Genotype | Day 7 | Day 8 | Day 9 | Day 12 | Day 15 |
WT | 2/10 (20%) | 5/10 (50%) | 8/10 (80%) | 10/10 (100%) | 10/10 (100%) |
tPA−/− | 6/18 (33%) | 11/18 (61%) | 15/18 (83%) | 10/10 (100%) | 10/10 (100%) |
uPA−/− | 3/18 (17%) | 5/18 (28%) | 7/18 (39%) | 8/10 (80%) | 10/10 (100%) |
P value | 0.476742 | 0.126956 | 0.010738* | 0.117319 | N/A |
The data are shown as the number of apparently closed TM perforations in relation to the total number of TM perforations examined at each examination time point (days 7, 8, 9, 12 and 15). The close rate was calculated and is shown in brackets. * P<0.05.