Table 2. Immunhistochemical analysis of the healing of TM perforations in WT, tPA−/− and uPA−/− mice.
Number of days after perforation | |||
Genotype | Day 9 | Day 12 | Day 15 |
WT | 6/10 (60%) | 9/10 (90%) | 10/10 (100%) |
tPA−/− | 11/18 (61%) | 9/10 (90%) | 10/10 (100%) |
uPA−/− | 1/18 (6%) | 6/10 (60%) | 10/10 (100%) |
P value | 0.000912*** | 0.153355 | N/A |
The data are shown as the number of closed TM perforations with a continuous keratin layer in relation to the total number of TM perforations examined. The healing rate was calculated and is shown in brackets. *** P<0.001.