Skip to main content
. 2012 Dec 7;7(12):e51363. doi: 10.1371/journal.pone.0051363

Figure 3. Preserved salivary flow rates in irradiated parotid glands pretreated with Roscovitine at acute time points.

Figure 3

Mice were treated as stated in Figure 1. Three days following radiation treatment, stimulated saliva was collected for five minutes immediately following an injection of carbachol. Abbreviations represent untreated (UT), irradiated with vehicle pre-treatment (IR+V), Roscovitine alone (Rosco), and Roscovitine prior to irradiation (IR+Rosco). A) Mice received a dose of 25 mg/kg Roscovitine prior to radiation treatment. B) Mice received a dose of 100 mg/kg Roscovitine prior to radiation treatment. Salivary flow was normalized to unirradiated controls (UT). Results are shown as the mean +/− SEM with at least eight mice per treatment group. C) Mice received a dose of 100 mg/kg Roscovitine prior to 2 Gy radiation treatment for five consecutive days. Salivary flow was collected 14 days after the final radiation treatment and normalized to unirradiated controls (UT). Results are shown as the mean +/− SEM with at least three mice per treatment group. Treatment groups with the same letters are not statistically different from each other.