Figure 4. Preserved salivary flow rates in irradiated parotid glands pretreated with Roscovitine at Day 30.

Mice were treated as stated in Figure 1. Chronic dysfunction was evaluated thirty days after radiation treatment using stimulated saliva collections for five minutes immediately following an injection of carbachol. Abbreviations represent untreated (UT), irradiated with vehicle pre-treatment (IR+V), Roscovitine alone (Rosco), and Roscovitine prior to irradiation (IR+Rosco). A) Mice received a dose of 25 mg/kg prior to radiation treatment. B) Mice received a dose of 100 mg/kg prior to radiation treatment. Salivary flow was normalized to untreated. Results are shown as the mean +/− SEM with at least eight mice per treatment group. Treatment groups with the same letters are not statistically different from each other.