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. 2012 Dec 7;7(12):e50698. doi: 10.1371/journal.pone.0050698

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© 2012 Bansal et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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We added deformations to copies of the template brain and then normalized those deformed brains to the undeformed template. The deformed brains were spatially normalized using a method that maximizes mutual information in the gray scale values across the images [32] and then warped the coregistered brain using a method based on fluid dynamics. [33] Because a deformed brain was identical to the template brain except for the added deformation, the deformation field only shows a large spatial deformation in the region of the added deformation.