Table 1. Associated loci with lipid traits in individuals of African, East Asian and Hispanic ancestry.
| African-Americans | Results IBC Europeans | ||||||||||||
| Trait | Chr | BP | Candidate Gene | SNP | Risk allele | RAF | Beta (SE) | P | % I2 | RAF | Beta (SE) | P | % I2 |
| TC | 1 | 55290748 | PCSK9 | rs11806638 | C | 0.68 | 0.11 (0.018) | 1.99×10−9 | 8 | 0.94 | 0.01 (0.013) | 0.28 | 0 |
| TC | 1 | 109619113 | CELSR2 | rs12740374 | G | 0.75 | 0.14 (0.019) | 4.43×10−13 | 0 | 0.76 | 0.13 (0.008) | 1.79×10−63 | 34.5 |
| TC | 2 | 21119200 | APOB | rs12720826 | T | 0.87 | 0.13 (0.025) | 7.84×10−8 | 0 | 0.999 | NA | NA | NA |
| TC | 2 | 210769915 | ACADL | rs6739874 | T | 0.05 | 0.17 (0.038) | 4.65×10−6 | 0 | 0.18 | NA | NA | NA |
| TC | 19 | 10249462 | ICAM1 | rs5030359 | G | 0.99 | 0.57 (0.098) | 5.22×10−9 | 0 | 0.998 | NA | NA | NA |
| TC | 19 | 11063306 | LDLR | rs6511720 | G | 0.86 | 0.18 (0.024) | 1.39×10−13 | 26.2 | 0.88 | 0.17 (0.009) | 1.81×10−73 | 24.3 |
| TC | 19 | 50112183 | APOE | rs389261 | A | 0.25 | 0.13 (0.020) | 2.07×10−11 | 0 | 0.001 | NA | NA | NA |
| LDL-C | 1 | 55290528 | PCSK9 | rs11800231 | G | 0.83 | 0.14 (0.022) | 1.02×10−10 | 37.3 | 0.96 | 0.009 (0.015) | 0.60 | 0 |
| LDL-C | 1 | 109619113 | CELSR2 | rs12740374 | G | 0.75 | 0.16 (0.019) | 1.92×10−17 | 0.8 | 0.75 | 0.12 (0.007) | 2.62×10−66 | 41.6 |
| LDL-C | 2 | 21141826 | APOB | rs562338 | G | 0.4 | 0.09 (0.017) | 6.54×10−8 | 0 | 0.82 | 0.12 (0.008) | 7.38×10−51 | 0 |
| LDL-C | 17 | 61641042 | APOH | rs1801689 | C | 0.007 | 0.49 (0.098) | 4.70×10−7 | 25.5 | 0.03 | 0.11 (0.016) | 8.57×10−12 | 0 |
| LDL-C | 19 | 10249462 | ICAM1 | rs5030359 | G | 0.99 | 0.51 (0.096) | 1.09×10−7 | 0 | 0.998 | NA | NA | NA |
| LDL-C | 19 | 11059187 | LDLR | rs17248720 | C | 0.73 | 0.11 (0.019) | 7.13×10−10 | 0 | 0.88 | 0.16 (0.009) | 8.81×10−72 | 37.5 |
| LDL-C | 19 | 50112183 | APOE | rs389261 | A | 0.25 | 0.14 (0.020) | 1.03×10−12 | 0 | 0.001 | NA | NA | NA |
| HDL-C | 7 | 80138385 | CD36 | rs3211938 | G | 0.09 | 0.06 (0.012) | 3.09×10−7 | 28.3 | 0.0005 | NA | NA | NA |
| HDL-C | 8 | 19868772 | LPL | rs13702 | C | 0.51 | 0.04 (0.007) | 1.34×10−9 | 46.8 | 0.3 | 0.04 (0.002) | 3.57×10−74 | 24 |
| HDL-C | 15 | 56511231 | LIPC | rs2070895 | A | 0.51 | 0.04 (0.007) | 4.16×10−8 | 0 | 0.21 | 0.04 (0.002) | 9.76×10−58 | 41.2 |
| HDL-C | 16 | 55553328 | CETP | rs17231520 | A | 0.07 | 0.19 (0.013) | 2.03×10−46 | 14.5 | 0.002 | 0.16 (0.044) | 3.28×10−04 | 0 |
| HDL-C | 16 | 66534352 | LCAT | rs35673026 | T | 0.004 | 0.28 (0.059) | 2.40×10−6 | 0 | 0.001 | NA | NA | NA |
| TG | 2 | 27584444 | GCKR | rs1260326 | T | 0.15 | 0.06 (0.012) | 5.54×10−7 | 13.7 | 0.41 | 0.06 (0.003) | 1.56×10−83 | 32.6 |
| TG | 8 | 19864004 | LPL | rs328 | C | 0.93 | 0.08 (0.016) | 1.74×10−7 | 19.9 | 0.9 | 0.08 (0.005) | 5.73×10−16 | 38.1 |
| TG | 11 | 116170289 | APOA5 | rs9804646 | C | 0.65 | 0.04 (0.009) | 2.55×10−6 | 2.3 | 0.92 | 0.02 (0.005) | 1.57×10−7 | 11.4 |
| TG | 19 | 50114427 | APOE | rs12721054 | A | 0.89 | 0.12 (0.013) | 1.01×10−21 | 2.7 | 0.998 | NA | NA | NA |
Chr chromosome, BP base pair, RAF risk allele frequency, SE standard error.