Fig. 1.

Renal cortical hemopexin (Hpx) protein levels rise following acute kidney injury (AKI). Renal cortical Hpx levels were measured following induction of glycerol AKI (gly; 24 h); cisplatin AKI (at 24 and 72 h); unilateral or bilateral ischemia-reperfusion (I/R)-induced AKI (24 h); or 4 or 24 h postendotoxin [lipopolysaccharide (LPS)] injection. Marked, but highly variable, renal cortical Hpx increases were observed compared with values seen in normal controls (C). Stepwise Hpx increases followed cisplatin and LPS injection. Notably, both sham surgery (used for the bilateral I/R experiment) and the contralateral (CL) kidneys from the unilateral ischemia experiment, were associated with elevated renal cortical Hpx levels vs. values observed in normal control mice.