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HEK 293 cell responses to hemin. A dose titration of HEK 293 cells with hemin failed to induce a significant change in Hpx mRNA levels. Conversely, a direct dose-response relationship between heme oxygenase 1 (HO-1) mRNA and hemin was observed. This indicates that the failure of Hpx mRNA responsiveness was not due to an inability of these cells to respond to hemin driven oxidant stress.
