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HK-2 cell responses to hemin- and Fe sucrose (FeS)-induced oxidant stress. HK-2 cells responded to hemin with a significant reduction, not an increase, in Hpx mRNA. Furthermore, FeS-mediated oxidant stress failed to raise Hpx mRNA levels. In contrast, the cells responded to both the hemin and FeS challenges with significant increases in HO-1 mRNA, indicating an ability to respond to Fe-mediated oxidative stress.
