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Hepatic Hpx mRNA levels rise in the setting of AKI. Each form of AKI evoked three- to fourfold increases in hepatic Hpx mRNA. Notably, sham surgery induced an almost identical increase in hepatic Hpx mRNA compared with bilateral I/R AKI. Thus surgical “stress,” and not the presence of I/R injury, was responsible for the hepatic Hpx mRNA elevations.
