Fig. 1.

Diagram of the basic study design for the baseline study and the 2-wk overeating period. After completing a 2-day “baseline” metabolic study, subjects were enrolled into either a “control” overeating group or a growth hormone (GH) treatment (GHT) group. All subjects ate 70 kcal·kg fat-free mass (FFM)⁻¹·day⁻¹ for 2 wk, and metabolic measurements were repeated after 3 days and after 2 wk of overeating. The only difference between the control and GHT groups was that subjects in the GHT groups received 4 daily intravenous injections of GH to prevent the suppression of GH that naturally occurs with overeating.