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. 2012 Aug 30;303(10):G1164–G1173. doi: 10.1152/ajpgi.00027.2012

Fig. 6.

Fig. 6.

Protein levels of alternate signaling pathways in response to different O2 exposure. No significant differences in catalytic (c)PKA were identified in cells subject to hypoxic or hyperoxic exposure (30 min, 120 min). A significant decrease in P-CREB protein levels was identified after 120 min of decreased O2 saturation. Decreasing the O2 resulted in a decrease in P-ERK at 120 min, but increasing O2 significantly decreased pERK at both time points. No changes in total ERK levels were identified. Reducing O2 significantly increased pAKT (120 min), but an elevated O2 was associated with a significant decrease in pAKT (30 min, 120 min). No changes in total AKT levels were identified. There was a significant increase in P-NF-κB after decreasing O2 (30 min, 120 min). No changes in total NF-κB levels were identified. Means ± SE, n = 4–16, *P < 0.01, #P < 0.05.