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Final saliva comparisons between model simulations and data for wild-type and chemically blocked channels. A: application of amiloride blocks the ENaC sodium channel. We represent this as a reduction in the sodium channel conductance (gblock Na+ = 0.2 × gA,Na+). B: cystic fibrosis transmembrane conductance regulator (CFTR) channel chemically blocked (gblock Cl−= 0.15 gA,Cl−).
