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Model variations against data from the wild-type and CFTRΔF/ΔF mouse final saliva. CFTRΔF/ΔF mouse model has the CFTR channel deleted. A: CFTR channel conductance is reduced (gΔCl− = 0.15 × gA,Cl−). Notice how the model sodium concentration for the deletion is unable to capture behavior as measured in the CFTRΔF/ΔF mouse. B: in addition to the CFTR channel reduction performed in A, the ENaC channel conductance is also reduced (gΔNa+ = 0.4 × gA,Na+).
