Fig. 4.

A: comparison between our model and the wild-type and K_Ca1.1 channel deletion final saliva (36). The K_Ca1.1 channel deletion is represented by a reduction in channel conductance, g_ΔK⁺ = 0.01 × g_A,K⁺. We also reduce the CFTR conductance due to the absence of IPR (36), g_{No IPR Cl⁻} = 0.5 × g_A,Cl⁻. A further reduction in the channel conductance will raise the final Cl⁻ concentration. B: AE activity is reduced and compared with the CFTR^ΔF/ΔF mouse. In addition to the parameter modifications in Fig. 3B, the AE activity is also reduced to 60%, g_ΔClHCO3 = g_A,ClHCO3× 0.6 (in black); to 40%, g_ΔClHCO3 = g_A,ClHCO3 × 0.4 (in gray); and to 20%, g_ΔClHCO3 = g_A,ClHCO3× 0.2 (in white). Slight decreases in Cl⁻ and increases in HCO₃⁻ occur as the activity is reduced.