Table 2.
Conductance parameters
| Conductance, nS/μm | |||
| gA,Na+ | 1.9/S | gB,Na+ | 9.7/S |
| gA,Cl− | 7.7/S | gB,Cl− | 14/S |
| gA,K+ | 3.0/S | gB,K+ | 36/S |
| gA,HCO3 | 1/4gCl | gB,HCO3 | 8.2/S |
| Density, ×10−14 mol/μm2 | |||
| gA,NaHCO3 | 2.1/S | gB,NaHCO3 | 300/S |
| gA,ClHCO3 | 2.26/S | gB,ClHCO3 | 520/S |
| gB,NaK | 0.15/S | ||
| Deletion/block conductances (fit to data) | |||
| gblock Na+ | 0.2 × gA,Na+ | ENaC block | |
| gblock Cl− | 0.15 × gA,Cl− | CFTR block | |
| gΔCl− | 0.15 × gA,Cl− | CFTR ΔF/ΔF | |
| gΔNa+ | 0.4 × gA,Na+ | ENaC reduction from CFTR ΔF/ΔF | |
| gΔClHCO3 | r × gA,ClHCO3 | CFTR ΔF/ΔF-dependent reduction, r = 0.2; 0.4 or 0.6 | |
| gΔK+ | 0.01 × gA,K+ | KCa1.1 deletion | |
| gNo IPR Cl− | 0.5 × gA,Cl− | Lower conductance in absence of IPR |
See text for definitions.