Fig. 5.

Pancreatitis-like injury resulting from lysosomal/autophagic dysfunction in genetic models. A: hematoxylin-eosin-stained section of pancreas of N-acetylglucosamine-1-phosphotransferase-deficient (Gnptab^−/−) mouse. Note large cytoplasmic vacuoles in acinar cells containing partially degraded cargo. [From Vogel et al. (105), by permission from Sage Publications.] B: electron micrograph showing accumulation of large autophagic vacuoles (arrowheads) in pancreas of LAMP-2-deficient mice. [From Tanaka et al. (100), by permission from Macmillan Publishers Ltd.]