Lung resistance is elevated in Brown Norway (BN) and Lewis pups following maternal allergen exposure. Airway resistance is significantly increased after OVA exposure in Lewis pups (top) after 12.5 mg of methacholine (MCh) (*P < 0.05, n = 4 SAL, n = 15 OVA), in BN (bottom) after 50 mg/ml of MCh (*P < 0.05, n = 5 SAL, n = 16 OVA). All measurements were taken at PN14.