Table 1.
Function and disease association with Brown Norway and Lewis rats
| Accession | Symbol | Corr BN | Corr L | Function and Disease Association |
|---|---|---|---|---|
| Brown Norway Rat | ||||
| XM_001069955.1 | Edg4 (LPA2) | −0.486 | −0.556 | LPA2, potent bioactive phospholipid, induces cell proliferation, migration, and cytokine release. (52) |
| NM_019195.2 | Cd47 | −0.926 | 0.069 | Antiangiogenic signaling: CD47 ligation to TSP1 inhibits Vegfr2 signaling. (17) |
| NM_001017445.1 | Faf2 | −0.836 | 0.278 | Highly expressed in peripheral blood of patients with AD. (1) |
| NM_020308.1 | Adam15 | −0.830 | 0.569 | Involved in cell adhesion and processing of cytokines. (1) |
| XM_001059464.1 | Cdh11 | −0.808 | −0.937 | Expression regulated by mediators of inflammation such as TNF-α. Plays a role in cartilage destruction in arthritis. (46) |
| NM_053963.1 | Mmp12 | −0.803 | 0.947 | Role in ECM remodeling. Degrades collagens I, III and elastin. Role in emphysema. Mmp12 allele associated with positive effect on lung function in children with asthma. (15, 44) |
| NM_031549.1 | Tagln(SM22) | −0.729 | 0.429 | Transgelin. Actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Is a direct target of TGF-β/Smad3-dependent epithelial cell migration in lung fibrosis. Increased expression in asthmatic lung. (24, 50) |
| NM_053288.1 | Orm1 | −0.596 | −0.267 | Mediator of sphingolipids homeostasis. Genetic variation in Ormdl3 identified as risk factor in childhood asthma. (6, 48) |
| NM_080698.1 | Fmod | −0.576 | −0.311 | Enhanced deposition in the airway wall of atopic asthmatics. (14) |
| NM_012878.1 | Sftpd | −0.546 | 0.315 | Surfactant associated protein with role in immune modulation. Sftpd expression markedly increases in response to acute lung injury and inflammation. (11) |
| XM_001078237.1 | Trim16 (EBBP) | −0.531 | 0.257 | Estrogen responsive B box protein (Ebbp). Role in innate immunity by enhancing pathway of interleukin-1β secretion. (30) |
| XM_001066152.1 | Egfl6 | −0.511 | 0.456 | Member of EGF family with key role in developmental processes in the lung. (1) |
| NM_139111.1 | Cklf | −0.510 | 0.938 | Chemokine-like factor. Potent chemoattractant for neutrophils, monocytes, and lymphocytes with role in inflammation. Stimulates antigen-presenting capability of immature dendritic cells. (41) |
| NM_031775.2 | Casp6 | −0.403 | 0.401 | Sequential activation of caspases regulate apoptosis. Neutrophils activate alveolar macrophages via Casp6-mediated cleavage of IL-1 Receptor-associated kinase-M. (22) |
| Lewis Rat | ||||
| XM_001069955.1 | Edg4 (LPA2) | −0.486 | −0.556 | LPA2. Potent bioactive phospholipid, induces cell proliferation, migration, and cytokine release. (52) |
| NM_053288.1 | Orm1 | −0.596 | −0.267 | Mediator of sphingolipid homeostasis. Genetic variation in Ormdl3 identified as risk factor in childhood asthma. (6, 48) |
| XM_001067182.1 | Myl9 | 0.063 | −0.975 | Myosin light chain, regulate muscle contraction by modulating the ATPase activity of myosin heads. (1) |
| NM_019904.1 | Lgals1 | 0.533 | −0.963 | Lectin, galactosidase-binding, soluble 1. Modulates cell-cell, cell-matrix interactions and cell proliferation. Mediates dendritic cell energy. Modulates release of cytokines involved in autoimmunity. (13, 23) |
| XM_001076104.1 | Mgst3 | 0.229 | −0.910 | Microsomal glutathione S-transferase 3. Involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. (1) |
| XM_342219.3 | Cpa3 | 0.975 | −0.907 | Carboxypeptidase A. Mast cell Cpa3 has a role in regulating innate immune responses. (35) |
| XM_579614.1 | Ifi271 | 0.528 | −0.898 | Interferon, α-inducible protein 27 interacts with steroid hormone and IFN in endometrium at implantation. (26) |
| XM_343604.3 | Serpine2 | 0.712 | −0.891 | Proposed susceptibility gene for COPD and related phenotypes. May be a risk factor for the development of emphysema. (12) |
| NM_053819.1 | Timp1 | 0.505 | −0.836 | Inhibitor of the MMPs involved in extracellular matrix degradation. Regulates proliferation/apoptosis Transcription induced by cytokines and hormones. (1) |
BN, Brown Norway; L, Lewis; LPA2, lysophosphatidic acid receptor; TSP1, thrombospondin 1; AD, atopic dermatitis; ECM, extracellular matrix; MMP, matrix metalloproteinase.