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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Int J Neuropsychopharmacol. 2012 Jul 31;16(4):869–888. doi: 10.1017/S1461145712000715

Fig. 3.

Fig. 3

Monoamine oxidase (MAO)A/B, but not MAOA-deficient mice show a significant impairment in learning reversal. (a–c) Typical locomotor pathways during the initial probe trial prior to training. (d–i) All genotypes exhibited a significant decrease in the percent time to reach the platform for spatial learning. (j–o) After reversal training, only wild-type (WT) mice displayed a significant reduction in the percent time to locate the platform, signifying learning acquisition. (p–r) MAOA/B knockout (KO) mice showed a significant reduction in both the total duration and the percent locomotor activity in the platform-associated target quadrant compared to WT mice. This was not caused by alterations in locomotor activity as no changes were found between MAOA/B KO and WT mice. Values are displayed as means±S.E.M. *p<0.05, **p<0.01 and ***p<0.001 compared to controls. #p<0.05 compared to MAOA KO mice. † p<0.05, †† p<0.01 and ††† p<0.001 compared to first trial within subject. For reversal learning n=6–9.