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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Int J Neuropsychopharmacol. 2012 Jul 31;16(4):869–888. doi: 10.1017/S1461145712000715

Fig. 6.

Fig. 6

Monoamine oxidase (MAO)A knockout (KO) and MAOA/B KO mice show significant disturbances in dendritic arbourization in the orbitofrontal cortex. (a) Schematic diagram of coronal sections through mouse prefrontal cortex. The coordinates indicate position relative to bregma (Paxinos & Franklin, 2001). (b) Computer-assisted reconstructions of Golgi-stained neurons in the orbitofrontal cortex in wild-type (WT), MAOA KO and MAOA/B KO mice. Scale bar: 50 μm. (c) Both MAOA and MAOA/B KO mice display an increase in the number and length of apical dendritic branches of pyramidal neurons in the orbitofrontal cortex. (d) Conversely, MAOA KO, but not MAOA/B KO mice exhibit a significant reduction in the number and length of basilar dendritic branches in the pyramidal neurons of the orbitofrontal cortex compared to their WT counterparts. Values are displayed as means±S.E.M. *p<0.05 compared to WT mice. For dendritic analyses n=6–7.