Fig. 10.

Effect of eldecalcitol compared with alfacalcidol. a Change in lumbar BMD. Data are mean ± SE, *p < 0.001 vs alfacalcidol group by Student t test (Matsumoto [12] (Copyright© 2011 Elsevier)). b Incidence of vertebral fracture. Hazard ratio (HR) is 0.74 and 95 % confidence interval (CI) is 0.56–0.97. Data from Matsumoto [12] (Copyright© 2011 Elsevier). c Incidence of non-vertebral fractures. HR for three major non-vertebral fractures is 0.52 and 95 % CI is 0.29–0.93, p = 0.031. Three major non-vertebral sites mean humerus, wrist, and hip, i.e., the three sites of major non-vertebral fractures recognized as osteoporotic fractures in FRAX®. HR for wrist fractures is 0.29 and 95 % CI is 0.11–0.77, p = 0.005. Data from Matsumoto [12] (Copyright© 2011 Elsevier) and the website of Pharmaceuticals and Medical Devices Agency (in Japanese)