Table 1.
Top 15 overrepresented GO biological processes among the up-regulated and down-regulated genes in the ERβ1 vs. control PC3 cells in the microarray comparison
| GO biological process | Accession | P value |
|---|---|---|
| Up-regulated | ||
| Regulation of transcription | 0006351 | 1.42E-07 |
| Transcription | 0006355 | 5.07E-07 |
| Response to testosterone stimulus | 0033574 | 4.82E-06 |
| Apoptosis | 0006915 | 2.60E-05 |
| Positive regulation of transcription from the RNA pol II promoter | 0045944 | 4.47E-05 |
| Positive regulation of apoptosis | 0043065 | 2.85E-04 |
| Artery morphogenesis | 0048844 | 8.80E-04 |
| Positive regulation of DNA binding | 0043388 | 1.91E-03 |
| Response to drug | 0042493 | 2.00E-03 |
| Nervous system development | 0007399 | 2.81E-03 |
| Endothelial cell fate specification | 0060847 | 2.95E-03 |
| Vitellogenesis | 0007296 | 2.95E-03 |
| Positive regulation of erythrocyte aggregation | 0034120 | 2.95E-03 |
| Actin polymerization-dependent cell motility | 0070358 | 2.95E-03 |
| Calcitonin catabolic process | 0010816 | 2.95E-03 |
| Down-regulated | ||
| Nucleosome assembly | 0006334 | 3.21E-30 |
| Translational elongation | 0006414 | 1.03E-04 |
| Nucleosome positioning | 0016584 | 3.52E-04 |
| Protein folding | 0006457 | 5.18E-04 |
| Organ regeneration | 0031100 | 7.14E-04 |
| Positive regulation of cell proliferation | 0008284 | 1.05E-03 |
| Protein polyubiquitination | 0000209 | 1.90E-03 |
| DNA unwinding involved in replication | 0000209 | 2.73E-03 |
| rRNA processing | 0006364 | 3.00E-03 |
| Translational initiation | 0006413 | 3.05E-03 |
| Positive regulation of caspase activity | 0043280 | 3.08E-03 |
| Translation | 0006412 | 3.17E-03 |
| Fatty acid transport | 0015908 | 3.85E-03 |
| Cell division | 0051301 | 4.58E-03 |
| Hepatic duct development | 0061011 | 4.89E-03 |
Pathway Studio enrichment analysis of GO groups with genes identified as differentially expressed as described in Materials and Methods. The P values were calculated with Fisher's exact test.