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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Stem Cells. 2012 Oct;30(10):2152–2163. doi: 10.1002/stem.1187

Figure 4.

Figure 4

Over-expression of TBX3 increases stem cell proliferation possibly by repressing the expression of NFκBIB and p14ARF. (A) Phase images of control (left) and TBX3 over-expressing (right) human ESC colonies cultured on MEFs. Examples of DAPI images used to calculate mitotic index. Mitotic cells are shown in insets. (B) TBX3 over-expressing ESCs have a significantly higher mitotic index than control ESCs. *, p<0.05. (C) TBX3 over-expression increases the percentage of BrdU positive ESCs cells. *, p<0.05 (D) TBX3 over-expression in human ESCs results in a significant decrease in the expression of cell cycle regulators, NFκBIB and p14ARF. *, p<0.05.