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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Stem Cells. 2012 Oct;30(10):2152–2163. doi: 10.1002/stem.1187

Figure 7.

Figure 7

Model for TBX3 regulation of human ESC proliferation and differentiation. In undifferentiated human ESCs, TBX3 may promote cell proliferation by repressing cell cycle regulators, NFκBIB and p14ARF. During differentiation, TBX3 may function to promote neuroepithelial differentiation while inhibiting differentiation into mesoderm and endoderm.