. 2012 Oct 25;12(10 HCC):e7635. doi: 10.5812/hepatmon.7635

Table 3. Hazard Ratio for the Development of HCC by Serum HBV DNA Levels ^a.

Serum HBV DNA level (copies/mL)	HR	95% CI	P value ^b
300-9999	1.4	0.5-3.8	0.56
10,000-99,999	4.5	1.8-11.4	0.001
100,000-999,999	11.3	4.5-28.4	< 0.001
≥ 1 million	17.7	6.8-46.3	< 0.001

Source: Chen CJ, Yang HI, Su J, et al. Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level. JAMA 2006; 295: 65-73.

^aHR values are based on comparison with participants with serum HBV DNA levels of less than 300 copies/mL. These results are from an analysis of a subset of 2925 participants seronegative for HBeAg, with normal ALT levels and no liver cirrhosis.

^bP value < 0.05 is statistically significant

Table 3. Hazard Ratio for the Development of HCC by Serum HBV DNA Levels a.

Table 3. Hazard Ratio for the Development of HCC by Serum HBV DNA Levels ^a.