Table 1.
Morphometric analysis of liver tissue of mice with RLS40 subjected to the treatment under Scheme 1.
| Passage number | Hepatocyte degeneration, Vv, % (Mean ± SEM) | Hepatocyte necrosis, Vv, % (Mean ± SEM) | ||||
|---|---|---|---|---|---|---|
| Healthy subjected to CHOP (n = 10) | RLS40 without treatment (n = 15) | RLS40 subjected to CHOP (n = 15) | Healthy subjected to CHOP (n = 10) | RLS40 without treatment (n = 15) | RLS40 subjected to CHOP (n = 15) | |
| Baseline* | 7.3 ± 0.7 | 11.4 ± 0.7 | 3.1 ± 0.5 | 7.6 ± 0.7 | ||
| 1† | 15.7 ± 0.9 | 16.1 ± 0.8 | 21.9 ± 0.7# | 12.6 ± 1 | 19.1 ± 1.0 | 23.1 ± 0.8# |
| 2‡ | 17.1 ± 1.0 | 22.2 ± 1.2∧ | 18.8 ± 0.7#∧ | 10.0 ± 0.8 | 25.1 ± 0.9∧ | 25.9 ± 0.9 |
| 3‡ | 15.4 ± 1.0 | 16.2 ± 0.6 | 15.1 ± 0.7∧ | 12.0 ± 0.8 | 29.7 ± 1.0∧ | 27.7 ± 0.9∧ |
| 4‡ | 16.0 ± 1.2 | 17 ± 0.8 | 15.5 ± 0.9∧ | 13.2 ± 1.2 | 33.8 ± 1.3∧ | 30.6 ± 1.0#∧ |
*Initial level determined just before treatment (6th day after tumor transplantation).
†At day 7 after the treatment.
‡At day 10 after the treatment.
∧ P ≤ 0.05 compared to the 1st passage within one group.
# P ≤ 0.05 compared to the group without treatment.